5-[[[[2-[[(4S)-4-[[4-[[(2-氨基-1,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]氨基]-4-羧基-1-氧代丁基]氨基]乙基]氨基]硫代甲酰]氨基]-2-(6-羟基-3-氧代-3H-氧杂蒽-9-基)苯甲酸钠盐
中文名称 | 5-[[[[2-[[(4S)-4-[[4-[[(2-氨基-1,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]氨基]-4-羧基-1-氧代丁基]氨基]乙基]氨基]硫代甲酰]氨基]-2-(6-羟基-3-氧代-3H-氧杂蒽-9-基)苯甲酸钠盐 |
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中文同义词 | 5-[[[[2-[[(4S)-4-[[4-[[(2-氨基-1,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]氨基]-4-羧基-1-氧代丁基]氨基]乙基]氨基]硫代甲酰]氨基]-2-(6-羟基-3-氧代-3H-氧杂蒽-9-基)苯甲酸钠盐;化合物 T19304 |
英文名称 | EC-17 (disodiuM salt) |
英文同义词 | EC-17 (disodiuM salt);5-[[[[2-[[(4S)-4-[[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]amino]-4-carboxy-1-oxobutyl]amino]ethyl]amino]thioxomethyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid sodium salt;QXZUFPLOUOSMBT-ARIINYJRSA-N |
CAS号 | 910661-33-5 |
分子式 | C42H34N10Na2O10S |
分子量 | 916.8249 |
EINECS号 | |
相关类别 | |
Mol文件 | 910661-33-5.mol |
结构式 |
5-[[[[2-[[(4S)-4-[[4-[[(2-氨基-1,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]氨基]-4-羧基-1-氧代丁基]氨基]乙基]氨基]硫代甲酰]氨基]-2-(6-羟基-3-氧代-3H-氧杂蒽-9-基)苯甲酸钠盐 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 黄至橙色 |
5-[[[[2-[[(4S)-4-[[4-[[(2-氨基-1,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]氨基]-4-羧基-1-氧代丁基]氨基]乙基]氨基]硫代甲酰]氨基]-2-(6-羟基-3-氧代-3H-氧杂蒽-9-基)苯甲酸钠盐 用途与合成方法
Folate receptor alpha
EC-17 contains the fluorescein fluorochrome and has a spectral wavelength of 490–530 nm. EC-17 is synthesized by a folate (vitamin B9) and fluorescein isothiocyanate (FITC) conjugated through an ethylenediamine spacer to produce folate-FITC, with a molecular weight of 917 kDa. FITC is a derivative of fluorescein functionalized with an isothiocyanate reactive group. The folate-FITC conjugate forms a negatively charged fluorescent molecule that specifically targets cell-surface FRα and is subsequently internalized into the cytoplasm. The signal-to-background ratio (SBR) of EC-17 for HeLa cells range from 0.97 to 7.32 depending on the molarity and concentration of cancer cells.
The mean fluorescence signal from the animals injected with EC-17 to be 42,234 ± 12,234 au. Fluorescence microscopy for folate-FITC shows a strong signal in all malignant tumors with FR-α expression and no signal in FR-α–negative malignant or benign lesions.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13615A | EC-17 disodium salt | 1 mg | 3400元 | |
2024/08/19 | HY-13615A | 5-[[[[2-[[(4S)-4-[[4-[[(2-氨基-1,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]氨基]-4-羧基-1-氧代丁基]氨基]乙基]氨基]硫代甲酰]氨基]-2-(6-羟基-3-氧代-3H-氧杂蒽-9-基)苯甲酸钠盐 EC-17 disodium salt | 910661-33-5 | 5mg | 8500元 |