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| | ARN-2966 Basic information |
| Product Name: | ARN-2966 | | Synonyms: | ARN-2966;2-PMAP;ARN2966(2-PMAP);ARN-2966;ARN 2966;Phenol, 2-[(2-pyridinylmethyl)amino]-;2-PMAP >=98% (HPLC);2-((pyridin-2-ylmethyl)amino)phenol;ARN-2966,β-amyloid peptide,inhibit,Abeta,ARN 2966,Inhibitor,Amyloid-β,ARN2966 | | CAS: | 102212-26-0 | | MF: | C12H12N2O | | MW: | 200.24 | | EINECS: | | | Product Categories: | | | Mol File: | 102212-26-0.mol |  |
| | ARN-2966 Chemical Properties |
| Melting point | 130 °C(Solv: chloroform (67-66-3); hexane (110-54-3)) | | Boiling point | 354.4±27.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 10.22±0.35(Predicted) | | color | Light yellow to yellow |
| | ARN-2966 Usage And Synthesis |
| Biological Activity | arn2966 is a potent post-transcriptional modulator of amyloid precursor protein (app) expression in transfected cho cells. the cho cell can produce app.[1]app is the amyloid precursor protein of alzheimer’s disease. alzheimer’s disease is a progressive dementia with the symptoms of neuronal degeneration, synaptic loss, and the deposition of amyloid fibrils in the brain. ab protein is the major constituent of the amyloid . then the ab protein derives from the amyloid precursor protein (app). it has been proved that app can stimulate neurite outgrowth in vitro. [2]the modulation of app expression of the arn2966 functions as a post-transcriptional modulation,which is different from other mechanisms such as inhibition of secretases. arn2966 showed dose dependant inhibition of aß40 and aß42 productions in app751sw transfected cho cells (ic50<1 mm for aß40), along with lowering the level of app and c83, and c99 peptides, while the level of app mrna was unaffected..[1]there has been ad transgenic mice model proved arn2966’s efficacy and tolerability in vivo. through the treatment of arn2966, the memory of mice has been improved and a load in the brain has been reduced. | | references | [1] ayodeji asuni ,xu kevin , etal. , an app translation modulator arn2966 reduces beta-amyloid deposition and prevents memory deficits in alzheimer's disease transgenic mice. alzheimer's & dementia: the journal of the alzheimer's association, july 2012volume 8, issue 4, supplement, page s744 ;
[2]williamson tg1, mok ss, henry a, etal. , secreted glypican binds to the amyloid precursor protein of alzheimer's disease (app) and inhibits app-induced neurite outgrowth. j biol chem. 1996 dec 6;271(49):31215-21. |
| | ARN-2966 Preparation Products And Raw materials |
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