5MG
| 中文名称 | 5MG |
|---|---|
| 中文同义词 | 塞马莫德盐酸盐 |
| 英文名称 | CNI-1493 |
| 英文同义词 | SeMapiMod (tetrahydrochloride);Semapimod hydrochloride;N,N'-bis[3,5-bis[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide,tetrahydrochloride;N,N'-bis[3-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]-5-[(Z)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide:tetrahydrochloride;Semapimod (tetrahydrochloride)(CNI-1493);CPSI-2364 tetrahydrochloride |
| CAS号 | 164301-51-3 |
| 分子式 | C34H53ClN18O2 |
| 分子量 | 781.37 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 164301-51-3.mol |
| 结构式 |  |
5MG 性质
| 储存条件 | -20°C, protect from light |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至黄色 |
|
IL-1β
|
IL-6
|
TNF-α
|
p38 MAPK
|
Semapimod tetrahydrochloride leads to a significant decrease of p38-MAPK phosphorylation in macrophages, proinflammatory gene expression of macrophage inflammatory protein-1alpha, interleukin-6, monocyte chemoattractant protein-1, and intercellular adhesion molecule-1, and neutrophil infiltration. Semapimod tetrahydrochloride completely abrogated nitric oxide production within the tunica muscularis.
Semapimod tetrahydrochloride desensitizes TLR signaling via its effect on the TLR chaperone gp96. Semapimod tetrahydrochloride inhibits ATP-binding and ATPase activities of gp96 in vitro (IC
50
≈0.2-0.4 μM). Semapimod tetrahydrochloride desensitizes TLR signaling via its effect on the TLR chaperone gp96.
Semapimod tetrahydrochloride (5 mg/kg; i.p; daily for 2 weeks) ameliorates endothelial dysfunction in Obese Zucker (OZ) rats.
Semapimod tetrahydrochloride restores AM-induced akt phosphorylation and cGMP production in OZ rats.
| Animal Model: | Male OZ rats |
| Dosage: | 5 mg/kg |
| Administration: | I.p; daily for 2 weeks |
| Result: | Restored endothelium-dependent vasorelaxation in OZ rats. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15509A | Semapimod tetrahydrochloride | 164301-51-3 | 5mg | 1900元 |
| 2024/04/30 | HY-15509A | Semapimod tetrahydrochloride | 164301-51-3 | 10 mg | 3250元 |