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| | Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Basic information |
| Product Name: | Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- | | Synonyms: | (2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone CCT007093;Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-;CCT007093;(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone;(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone;2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone;CCTOO7093;2,5-Bis(2-thienylmethylene)-cyclopentanone | | CAS: | 176957-55-4 | | MF: | C15H12OS2 | | MW: | 272.39 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 176957-55-4.mol |  |
| | Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Chemical Properties |
| Melting point | 222-223℃ | | storage temp. | 2-8°C | | solubility | DMSO: >3mg/mL | | form | powder, yellow | | Sensitive | Light Sensitive |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Usage And Synthesis |
| Uses | Acts as a PPM1D inhibitor | | Biological Activity | cct007093 is a small-molecule chemical inhibitor of ppm1d with ic50 value of 8.4μm [1].cct007093 is a thienylidene cyclopentanone and shows a potent inhibition of ppm1d in the in vitro assay when using the recombinant phospho-p38 as a substrate. in cellular assay, cct007093 shows specificity for mcf-7 cells over hela cells. it reduces 40% viability of the cells after 2 days. it is found that the cell death induced by cct007093 is dependent on p38 kinase activity. cct007093 mimics the effect of ppm1d rnai in activating p38 kinase. it induces p38 phosphorylation at 4 h post-exposure in mcf-7 cells and the loss of viability can be rescued by sb203580, the specific p38 inhibitor [1]. | | target | WIP1 | | references | [1] rayter s, elliott r, travers j, rowlands mg, richardson tb, boxall k, jones k, linardopoulos s, workman p, aherne w, lord cj, ashworth a. a chemical inhibitor of ppm1d that selectively kills cells overexpressing ppm1d. oncogene. 2008 feb 14;27(8):1036-44. |
| | Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Preparation Products And Raw materials |
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