Z62954982
| 中文名称 | Z62954982 |
|---|---|
| 中文同义词 | |
| 英文名称 | Rac1 Inhibitor II |
| 英文同义词 | Rac1 Inhibitor II;Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem;InSolution Rac1 Inhibitor II, Z62954982 - CAS 1090893-12-1 - Calbiochem;Benzamide, N-[3-(aminosulfonyl)-4-methylphenyl]-3-[(3,5-dimethyl-4-isoxazolyl)methoxy]-;Z62954982 (Synonyms: ZINC08010136);Z-62954982,Z62954982 |
| CAS号 | 1090893-12-1 |
| 分子式 | C20H21N3O5S |
| 分子量 | 415.46 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1090893-12-1.mol |
| 结构式 |  |
Z62954982 性质
| 储存条件 | -20C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 类白色固体 |
| 颜色 | 白色至米白色 |
Z62954982 (5-100 μM; 4 hours) reduces the intracellular levels of Rac1- GTP in a concentration-dependent manner,and shows the most potent inhibitory action with an IC 50 of 12.2 μM in Human SMCs.Z62954982 (25 μM; 4 hours) significantly reduces the ratio Rac1-GTP/Rac1 and has the most potent inhibitory action (86.0%) in cultured SMCs.Z62954982 (10-100 μM; 72 hours) causes a concentration-dependent decrease in transendothelial electrical resistance (TER) in both HDMEC and HUVEC monolayers.
Z62954982 (intraperitoneal injection; 10 mg/kg every other day or 20 mg/kg daily; 3 weeks) has no obvious signs of toxicity and decreases both phosphorylation of p38 as well as secreted IL-6 in PASMCs in response to hypoxia in both abr -/- and bcr -/- mice.
| Animal Model: | Male bcr -/- , abr -/- and wt mice (8 to 10-week-old littermates) are exposed to hypoxia (10% O2) or normoxia (21% O2) for 3 weeks |
| Dosage: | 10 mg/kg or 20 mg/kg |
| Administration: | Intraperitoneal injection; 10 mg/kg every other day or 20 mg/kg daily; 3 weeks |
| Result: | Promoted phosphorylation of p38 MAPK and increased IL-6 in Hypoxia in mice. |