ACK1-B19 manufacturers
- ACK1-B19
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- $1.00 / 1g
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2019-12-23
- CAS:1234480-46-6
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 200kg
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| | ACK1-B19 Basic information |
| Product Name: | ACK1-B19 | | Synonyms: | ACK1-B19;XMD8-87;CS-2588;XMD-8-87;XMD8 87;XMD 8 87;2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one;5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-;XMD8-87 (ACK1-B19) | | CAS: | 1234480-46-6 | | MF: | C24H27N7O2 | | MW: | 445.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1234480-46-6.mol |  |
| | ACK1-B19 Chemical Properties |
| density | 1.283±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | 10.18±0.20(Predicted) | | color | White to yellow |
| | ACK1-B19 Usage And Synthesis |
| Description | XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM in HEK293T cells expressing human TNK2. It is selective for TNK2 over a panel of approximately 100 kinases with >90 and <50% inhibition for TNK2 and all other kinases tested, respectively. XMD8-87 inhibits growth of Ba/F3 cells expressing constitutively active mutant TNK2s (IC50s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC50 = >1 μM). | | Uses | XMD8-87 is used in the studies of benzopyrimidodiazepinones as most selective and potent ERK5 inhibitor. |
| | ACK1-B19 Preparation Products And Raw materials |
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