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| ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Basic information |
Product Name: | ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate | Synonyms: | Empagliflozin impurity H;Dapagliflozin Impurity L;Empagliflozin-4;Dapagliflozin impurity 12/
O-Desethyl Dapagliflozin/(3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;Daglitele Impurity 6;D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-, (1S)-;Jardiance Impurity H;(3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-
(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | CAS: | 864070-37-1 | MF: | C19H21ClO6 | MW: | 380.82 | EINECS: | | Product Categories: | | Mol File: | 864070-37-1.mol | ![((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Structure](CAS/20150408/GIF/864070-37-1.gif) |
| ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Chemical Properties |
Boiling point | 628.3±55.0 °C(Predicted) | density | 1.459±0.06 g/cm3(Predicted) | storage temp. | -20°C | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml | form | A crystalline solid | pka | 10.17±0.15(Predicted) | Stability: | Hygroscopic |
| ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Usage And Synthesis |
Uses | O-Desethyl Dapagliflozin is derivative of antidiabetic drug Dapagliflozin (D185370), which is sodium-glucose transporter 2 inhibitor. |
| ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Preparation Products And Raw materials |
Raw materials | D-Glucopyranoside, methyl 1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]--->SDZNDOYQCYOLJI-ZCCUTQAASA-N-->(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol-->(3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol-->(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4- hydroxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate-->Silane,[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy](1,1-diMethylethyl)diMethyl--->Dapagliflozin | Preparation Products | Bexagliflozin-->Dapagliflozin-d5 |
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