- ASP-9521
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- $1.00 / 1g
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2021-01-06
- CAS:1126084-37-4
- Min. Order: 1g
- Purity: Min98% HPLC/GC
- Supply Ability: g/kg/ton Coreychem-Nicole
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| | ASP-9521 Basic information |
| Product Name: | ASP-9521 | | Synonyms: | ASP-9521;1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol;AKR1C3 inhibitor;ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR;[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone;17HSD5 inhibitor;ASP 9521. AKR1C3 inhibitor;ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR | | CAS: | 1126084-37-4 | | MF: | C19H26N2O3 | | MW: | 330.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1126084-37-4.mol |  |
| | ASP-9521 Chemical Properties |
| Boiling point | 543.9±30.0 °C(Predicted) | | density | 1.183±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM) | | form | A crystalline solid | | pka | 15.23±0.29(Predicted) | | color | Light yellow to yellow |
| | ASP-9521 Usage And Synthesis |
| Description | ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC50 = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model. | | Uses | ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). AKR1C3 is a promising therapeutic target in castration-resistant prostate cancer |
| | ASP-9521 Preparation Products And Raw materials |
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