| Company Name: |
Artis Biotech Co. Ltd.
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| Tel: |
19138486554 18582380095 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:3 Hydroxy Midostaurin
CAS:179237-49-1
Purity:98% HPLC Package:5mg 20mg 50mg 100mg 200mg 1g
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| Company Name: |
Chengdu Novel Biomedical Co., Ltd.
|
| Tel: |
028-85255396 18302801538 |
| Email: |
cdnovell@163.com |
| Products Intro: |
Product Name:3 Hydroxy Midostaurin
CAS:179237-49-1
Purity:98% HPLC Package:100mg；200mg
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| | CGP52421 Basic information |
| Product Name: | CGP52421 | | Synonyms: | CGP52421;3-Hydroxy Midostaurin (CGP 52421);Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-;Midostaurin Impurity 1 (3-Hydroxy Midostaurin);3-Hydroxy Midostaurin D5Q: What is
3-Hydroxy Midostaurin D5 Q: What is the CAS Number of
3-Hydroxy Midostaurin D5;Midostaurin metabolite - CGP52421;3-Hydroxy Midostaurin;N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide | | CAS: | 179237-49-1 | | MF: | C35H30N4O5 | | MW: | 586.65 | | EINECS: | | | Product Categories: | | | Mol File: | 179237-49-1.mol |  |
| | CGP52421 Chemical Properties |
| density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 12.23±0.70(Predicted) | | color | Light yellow to yellow |
| | CGP52421 Usage And Synthesis |
| Uses | 3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit. | | Biological Activity | 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic. | | in vitro | CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM. | | target | IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma) |
| | CGP52421 Preparation Products And Raw materials |
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