| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PD-321852
CAS:622856-21-7
Purity:详情请点击官网 Package:1 mg
|
|
| | PD-321852 Basic information |
| Product Name: | PD-321852 | | Synonyms: | PD-321852;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2,6-dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]- | | CAS: | 622856-21-7 | | MF: | C24H19Cl2N3O3 | | MW: | 468.33 | | EINECS: | | | Product Categories: | | | Mol File: | 622856-21-7.mol |  |
| | PD-321852 Chemical Properties |
| density | 1.53±0.1 g/cm3(Predicted) | | pka | 8.53±0.20(Predicted) |
| | PD-321852 Usage And Synthesis |
| Description | PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines. |
| | PD-321852 Preparation Products And Raw materials |
|