Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:PD-321852 CAS:622856-21-7 Purity:详情请点击官网 Package:1 mg
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| PD-321852 Basic information |
Product Name: | PD-321852 | Synonyms: | PD-321852;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2,6-dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]- | CAS: | 622856-21-7 | MF: | C24H19Cl2N3O3 | MW: | 468.33 | EINECS: | | Product Categories: | | Mol File: | 622856-21-7.mol | ![PD-321852 Structure](CAS/20210111/GIF/622856-21-7.gif) |
| PD-321852 Chemical Properties |
density | 1.53±0.1 g/cm3(Predicted) | pka | 8.53±0.20(Predicted) |
| PD-321852 Usage And Synthesis |
Description | PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines. |
| PD-321852 Preparation Products And Raw materials |
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