2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide CAS#: 1030203-81-6

2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide

生物活性靶点体外研究用途与合成方法 MSDS 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide价格(试剂级) 上下游产品信息

中文名称	2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
中文同义词	化合物 T27554;化合物HS38;2-((1-(3-氯苯基)-4-氧代-4,5-二氢-1H-吡唑并[3,4-D]嘧啶-6-基)硫基)丙酰胺;HS 38,ATP竞争性DAPK和ZIPK抑制剂
英文名称	2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
英文同义词	2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide;2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide;HS38;NASYEGAVCTZSDO-UHFFFAOYSA-N;HS-38 (HS38);Propanamide, 2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-;HS38 >=95% (HPLC);2-((1-(3-Chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)propanamide
CAS号	1030203-81-6
分子式	C14H12ClN5O2S
分子量	349.8
EINECS号
相关类别
Mol文件	1030203-81-6.mol
结构式

2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide 性质

沸点	615.0±65.0 °C(Predicted)
密度	1.65±0.1 g/cm3(Predicted)
储存条件	2-8°C
溶解度	DMSO：可溶5mg/mL，澄清（加热）
酸度系数(pKa)	14.95±0.50(Predicted)
形态	粉末
颜色	白色至米色

2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide 用途与合成方法

生物活性

HS38 是一种高效、选择性的，ATP 竞争性的 DAPK1 和 ZIPK (DAPK3) 抑制剂，Kd 值分别为 300 nM 和 280 nM。HS38 也是 PIM3 的抑制剂，其 IC50 值为 200 nM。HS38 可用于平滑肌相关疾病的研究。

靶点

Kd: 300 nM (DAPK1), 79 nM (DAPK2), 280 nM (ZIPK), IC50: 200 nM (DAPK1), 200 nM (PIM3)

体外研究

HS38 displays high affinity toward DAPK2, with a K _d of 79 nM. DAPK2 is not implicated in smooth muscle contractility.
HS38 significantly reduces relative RLC20 phosphorylation in both the basal and sphingosine 1-phosphate (S1P) activated states in human aortic SM cells.
HS38 reduces contractile forces generated by intact mouse aorta in aortic tissue.
HS38 reduces the contractile force, RLC20 phosphorylation, and MYPT1 phosphorylation in Ca ²⁺ -sensitized rabbit ileum.

Western Blot Analysis

Cell Line:	CA-VSMCs
Concentration:	10 µM
Incubation Time:	40 minutes
Result:	Reduced relative RLC20 phosphorylation in both the basal and S1P activated states.

安全信息

危险品标志	Xi
危险类别码	36/37/38
安全说明	26
WGK Germany	3

MSDS信息

2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-15847	2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide HS38	1030203-81-6	5mg	550元
2024/04/30	HY-15847	HS38		10 mM * 1 mLin DMSO	605元

2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide