|
|
| | ICA 110381 Basic information |
| Product Name: | ICA 110381 | | Synonyms: | ICA 110381;ICA-11038;4-Chloro-N-(6-chloro-3-pyridinyl)benzamide;4-CHLOR-N-(6-CHLOR-PYRIDIN-3-YL)-BENZAMID;4-Chloro-N-(6-chloro-pyridin-3-yl)-benzamide;ICA 110381; ICA110381;ICA 110381 (Compound 16);inhibit,ICA 110381,Potassium Channel,ICA-110381,KcsA,ICA110381,Inhibitor | | CAS: | 325457-99-6 | | MF: | C12H8Cl2N2O | | MW: | 267.11 | | EINECS: | | | Product Categories: | | | Mol File: | 325457-99-6.mol |  |
| | ICA 110381 Chemical Properties |
| Boiling point | 336.8±37.0 °C(Predicted) | | density | 1.440±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml). | | form | solid | | pka | 11.34±0.70(Predicted) | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | ICA 110381 Usage And Synthesis |
| Description | ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM).1?KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity?in vivo.2 | | Uses | ICA 110381 was used to study the pharmacological activities as it selectively activated human KCNQ2 expressed in Chinese hamster ovary, damped neuronal excitability in rat hippocampal CA1 cell and showed anticonvulsant activity in amygdala-kindled rat. | | storage | Store at +4°C | | References | 1) Amato?et al. (2011),?N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy; Sci. ACS Med. Chem. Lett.,?2?481
2) Boehlen?et al. (2013),?The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)benzamid displays anticonvulsant potential; Br. J. Pharmacol.,?168?1182 |
| | ICA 110381 Preparation Products And Raw materials |
|