|
|
| | Tos-PEG2-CH2CO2tBu Basic information |
| Product Name: | Tos-PEG2-CH2CO2tBu | | Synonyms: | Tos-PEG2-CH2CO2tBu;tert-Butyl 2-[2-(tosyloxy)ethoxy]acetate;Tos-PEG1-CH2-Boc;Acetic acid, 2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester;Tert butyl 2- (2- (p-toluenesulfonyloxy) ethoxy) acetate;Tos-PEG1-CH2COOtBu | | CAS: | 1643957-24-7 | | MF: | C15H22O6S | | MW: | 330.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1643957-24-7.mol |  |
| | Tos-PEG2-CH2CO2tBu Chemical Properties |
| Boiling point | 449.0±30.0 °C(Predicted) | | density | 1.183±0.06 g/cm3(Predicted) |
| | Tos-PEG2-CH2CO2tBu Usage And Synthesis |
| Description | Tos-PEG2-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | | Uses | Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
| | Tos-PEG2-CH2CO2tBu Preparation Products And Raw materials |
|