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| | CREB inhibitor (666-15) Basic information |
| Product Name: | CREB inhibitor (666-15) | | Synonyms: | CREB inhibitor (666-15);compound3i(666-15);CREB inhibitor;compound3i;CREB 666-15;666-15;3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride;breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor | | CAS: | 1433286-70-4 | | MF: | C33H31Cl2N3O5 | | MW: | 620.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1433286-70-4.mol |  |
| | CREB inhibitor (666-15) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 5mg/mL; DMSO: 5mg/mL | | form | A solid | | color | White to off-white | | Stability: | Hygroscopic |
| | CREB inhibitor (666-15) Usage And Synthesis |
| Uses | 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide Hydrochloride has been identified as an antitumor agent. | | Biological Activity | CREB inhibitor (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM. It also inhibits the growth of cancer cells without affecting normal cells. | | in vitro | 666-15 can effectively inhibit the growth of cancer cells. In MDA-MB-231 and MDA-MB-468 cells, the GI50 values of 666-15 were 73 nM and 46 nM, respectively. 666-15 also had strong activity in A549 and MCF-7 cells, with GI50 of 0.47 μM and 0.31 μM, respectively. 666-15 inhibits the transcriptional activity of CREB in live cells that do not depend on direct CREB or CBP binding reactions. | | in vivo | In the in vivo MDA-MB-468 xenograft tumor model, 666-15 completely inhibited tumor growth without obvious toxicity. Intraperitoneal injection of 10 mg/kg of 666-15 in mice was well tolerated. | | target | | Target | Value | CREB
() | 81 nM |
| | storage | Desiccate at RT |
| | CREB inhibitor (666-15) Preparation Products And Raw materials |
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