- AS1842856
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- $0.01 / 1KG
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2020-01-10
- CAS:836620-48-5
- Min. Order: 1KG
- Purity: 98%; 99%
- Supply Ability: 500g;1kg； 25kg
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| | AS1842856 Basic information |
| Product Name: | AS1842856 | | Synonyms: | AS1842856;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;CS-2538;AS 1842856;AS-1842856;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo- | | CAS: | 836620-48-5 | | MF: | C18H22FN3O3 | | MW: | 347.38 | | EINECS: | | | Product Categories: | | | Mol File: | 836620-48-5.mol |  |
| | AS1842856 Chemical Properties |
| Boiling point | 587.3±50.0 °C(Predicted) | | density | 1.370±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO:5.0(Max Conc. mg/mL);14.39(Max Conc. mM) | | form | A crystalline solid | | pka | 6.47±0.50(Predicted) | | color | White to light yellow |
| | AS1842856 Usage And Synthesis |
| Description | AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes., | | Uses | AS 1842856 is a novel FoxO1 antagonist with anti-obesity effects. | | Definition | ChEBI: AS1842856 is a quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. It has a role as a hypoglycemic agent, an anti-obesity agent, an autophagy inhibitor, an antineoplastic agent, an apoptosis inducer and a forkhead box protein O1 inhibitor. It is a quinolinemonocarboxylic acid, a quinolone, an organofluorine compound, a primary amino compound, a secondary amino compound and a tertiary amino compound. | | storage | Store at -20°C |
| | AS1842856 Preparation Products And Raw materials |
| Raw materials | 3-Quinolinecarboxylic acid, 1-ethyl-5,6,7-trifluoro-1,4-dihydro-4-oxo-, ethyl ester-->3-Quinolinecarboxylic acid, 5-amino-1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester-->3-Quinolinecarboxylic acid, 5-amino-1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo--->3,4,5-Trifluoroaniline-->Cyclohexylamine |
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