| Company Name: |
Shanghai Chaolan Chemical Technology Center Gold
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:t-AUCB
CAS:885012-33-9
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
TaiChem Taizhou Limited
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| Tel: |
052386810091 |
| Email: |
zcwy9518@yeah.net |
| Products Intro: |
Product Name:4-(((trans-4-(3-(adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid
CAS:885012-33-9
Purity:95% Package:1G;2G;5G
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| | trans-ACUB Basic information |
| Product Name: | trans-ACUB | | Synonyms: | trans-ACUB;trans-AUCB;4-(((trans-4-(3-(Adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid;trans-4-(4-[3-Adamantan-1-yl-ureido]-cyclohexyloxy)-benzoic acid;4-(((1R,4r)-4-(3-((3S,5S,7S)-adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid;Benzoic acid, 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-;t-AUCB;epoxide,anti-glioma,transAUCB,hydrolase,activity,orally,trans-AUCB,sEH,trans AUCB,active,Inhibitor,inhibit,soluble,Epoxide Hydrolase | | CAS: | 885012-33-9 | | MF: | C24H32N2O4 | | MW: | 412.52 | | EINECS: | | | Product Categories: | | | Mol File: | 885012-33-9.mol |  |
| | trans-ACUB Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤30mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | crystalline solid | | color | White to off-white |
| | trans-ACUB Usage And Synthesis |
| Uses | trans-ACUB is a potent inhibitor of soluble epoxide hydrolase (sEH) which is known to convert epoxides to their corresponding diols. Inhibitors of sEH act as anti-inflammatory, anti-hypertensive and cardioprotective agents. | | Biological Activity | trans-aucb is a potent inhibitor of soluble epoxide hydrolase (seh).soluble epoxide hydrolase (seh) can convert epoxides to their corresponding diols. inhibitors of seh have anti-hypertensive, anti-inflammatory, neuroprotective, and cardioprotective effects. | | in vitro | a previous study showed that the pretreatment with dapt could substantially potentiate the growth inhibition caused by t-aucb in u251 and u87 cells. moreover, the pretreatment with dapt markedly increased t-aucb-induced apoptosis of u251 and u87 cells. moreover, t-aucb alone did not obviously affect caspase-3 activity in the cells, but t-aucb plus dapt pretreatment caused significant increase of caspase-3 activity. in addition, the pretreatment with dapt was able to completely block t-aucb-induced phosphorylation of p38 mapk, mapkapk2 and hsp27 in the cells [1]. | | in vivo | a previous animal study was conducted to investigate the effects of acute seh inhibition by t-aucb on infarct volume, functional outcome, and changes in cerebral blood flow (cbf) in a rat model of ischemic stroke. it was found that t-aucb could significantly reduce cortical infarct volume by 35%, elevate cumulative epoxyeicosatrienoic acids-to-dihydroxyeicosatrienoic acids ratio in brain cortex by twofold, and improve functional outcome in arm-flexion test when compared with that of the vehicle-treated group [2]. | | IC 50 | 0.5 nm | | references | [1] li jy, li rj, wang hd. γ-secretase inhibitor dapt sensitizes t-aucb-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 mapk/mapkapk2/hsp27 pathway. acta pharmacol sin. 2014 jun;35(6):825-31.
[2] shaik js, ahmad m, li w, rose me, foley lm, hitchens tk, graham sh, hwang sh, hammock bd, poloyac sm. soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke. am j physiol heart circ physiol. 2013 dec 1;305(11):h1605-13. |
| | trans-ACUB Preparation Products And Raw materials |
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