- ONO4059 hydrochloride
-
- $9.00 / 1KG
-
2022-02-25
- CAS:1439901-97-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10KG
- ONO4059 hydrochloride
-
- $9.00 / 1KG
-
2022-02-25
- CAS:1439901-97-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
- ONO4059 hydrochloride
-
- $9.00 / 1KG
-
2022-02-25
- CAS:1439901-97-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10kg
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| | ONO-4059 (hydrochloride) Basic information |
| Product Name: | ONO-4059 (hydrochloride) | | Synonyms: | ONO-4059 (hydrochloride);(R)-6-amino-9-(1-but-2-ynoylpyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one;ONO-4059(GS4059) hydrochloride;ONO-4059 HCl;(R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride;(R)-6-amino-9-(1-but-2-ynoylpyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one HCl salt;ONO-4059(HCl salt);ON 0459 | | CAS: | 1439901-97-9 | | MF: | C25H23ClN6O3 | | MW: | 490.95 | | EINECS: | 946-274-3 | | Product Categories: | | | Mol File: | 1439901-97-9.mol |  |
| | ONO-4059 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | ONO-4059 (hydrochloride) Usage And Synthesis |
| Uses | ONO-4059 hydrochloride is a potent orally active BTK (Bruton's tyrosine kinase) inhibitor, IC50: 2.2nM.It is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration,it covalently binds to BTK within B cells,thereby preventing B-cell receptor signaling and impeding B-cell development. | | Biological Activity | Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with IC50 of 2.2 nM. | | in vitro | Compared with Lck, Fyn, LynA, ONO-4059 is more selective for BTK, and only inhibits anti-IgM-induced B cell activation in a concentration-dependent manner, but not anti-CD3/CD28-induced Activation of human PBMCs to T lymphocytes. ONO/GS-4059 inhibited cell proliferation in some malignant B cells, but also in the nanomolar concentration range, induced the classical apoptotic response of TMD8 cells. | | in vivo | In the CIA mouse model, ONO-4059 exerted its curative effect by inhibiting the production of inflammatory chemokines and cytokines such as IL-6, IL-8, TNFalpha, etc. in monocytes, accompanied by cartilage erosion, bone damage, vascular Recession of nebula formation. In preclinical animal models and clinical CLL and NHL patients, ONO-4059 has antitumor activity, good safety and long-lasting efficacy. | | target | |
| | ONO-4059 (hydrochloride) Preparation Products And Raw materials |
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