Company Name: |
Sigma-Aldrich
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Tel: |
021-61415566 800-8193336 |
Email: |
orderCN@merckgroup.com |
Products Intro: |
Product Name:Monoclonal Anti-Dystrophin antibody produced in mouse Purity:clone MANDYS8, ascites fluid Package:100UL Remarks:D8168-100UL
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| ANTI-DYSTROPHIN Basic information |
| ANTI-DYSTROPHIN Chemical Properties |
storage temp. | -20°C | form | buffered aqueous glycerol solution |
Hazard Codes | Xn | Risk Statements | 21/22-22 | Safety Statements | 36/37 | WGK Germany | 3 |
| ANTI-DYSTROPHIN Usage And Synthesis |
Uses | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunofluorescence (1 paper) Western Blotting (1 paper) | Uses | Monoclonal Anti-Dystrophin antibody produced in mouse has been used in
- immunohistochemistry
- immunofluorescence
- double immunofluorescence terminal dUTP nick-end labeling (TUNEL)
- immunoblotting
| General Description | Monoclonal Anti-Dystrophin (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Dystrophin is a structural protein on the inner face of the membrane, consisting of a 25-repeat, rod-like, triple-helical domain separating an N-terminal actin binding domain from two C-terminal domains, one of which is rich in cysteine. | Biochem/physiol Actions | In striated muscle cells, DMD (dystrophin) acts as a component of the multimeric protein dystrophin-associated glycoprotein (DGC) complex. It helps DGC to adhere with the extracellular matrix for various signalling pathways. It helps to maintain structural assembly of plasma membrane, regulates ion homeostasis and transmembrane signaling cascade. It stabilzes muscle fiber cells. It is associated with various muscular dystrophies, such as Duchenne/Becker muscular dystrophy, congenital muscular dystrophy and different forms of limb-girdle muscular dystrophy. |
| ANTI-DYSTROPHIN Preparation Products And Raw materials |
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