| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:AZ 12216052
CAS:1290628-31-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
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AZ 12216052 manufacturers
- AZ12216052
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- $52.00 / 1mg
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2024-11-17
- CAS:1290628-31-7
- Min. Order:
- Purity: 99.29%
- Supply Ability: 10g
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| | AZ 12216052 Basic information |
| Product Name: | AZ 12216052 | | Synonyms: | AZ 12216052;2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide;AZ12216052 >=98% (HPLC);Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]- | | CAS: | 1290628-31-7 | | MF: | C19H22BrNOS | | MW: | 392.35308 | | EINECS: | | | Product Categories: | | | Mol File: | 1290628-31-7.mol |  |
| | AZ 12216052 Chemical Properties |
| Boiling point | 526.9±45.0 °C(Predicted) | | density | 1.323±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 13.70±0.70(Predicted) | | color | White to off-white |
| | AZ 12216052 Usage And Synthesis |
| Description | AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM). In a cell-based model of Parkinson’s disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM. AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively. | | Uses | AZ 12216052 is a positive allosteric modulator of mGluR8, which are attractive therapeutic targets for anxiety disorders. |
| | AZ 12216052 Preparation Products And Raw materials |
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