| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:NG25 trihydrochloride
CAS:2108554-00-1
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:NG 25 (hydrochloride)
CAS:2108554-00-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:NG25 trihydrochloride
CAS:2108554-00-1
Purity:详情请点击官网 Package:1 mg
|
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| | NG 25 trihydrochloride Basic information |
| | NG 25 trihydrochloride Chemical Properties |
| | NG 25 trihydrochloride Usage And Synthesis |
| Description | NG-25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner. It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer. |
| | NG 25 trihydrochloride Preparation Products And Raw materials |
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