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Hangzhou Peptidego Biotech Co.,Ltd.
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0571-87213919 |
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eric@peptidego.com |
| Products Intro: |
Product Name:H-D-Phe-Phe-Arg-chloromethylketone
CAS:649748-23-2
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:PPACKII trifluoroacetate salt
CAS:649748-23-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:PPACKII (trifluoroacetate salt)
CAS:649748-23-2
Purity:98% Package:10mg; 5mg; 25mg Remarks:Medbio
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| Company Name: |
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
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| Tel: |
0571-87213919 17306812703 |
| Email: |
3007955328@qq.com |
| Products Intro: |
Product Name:H-D-Phe-Phe-Arg-chloromethylketone
CAS:649748-23-2
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
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| Tel: |
025-58851786 17714337195 |
| Email: |
sales@tybiochem.com |
| Products Intro: |
Product Name:PPACKII (trifluoroacetate salt)
CAS:649748-23-2
Purity:95+% Package:1g;5g
|
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| | PPACKII (trifluoroacetate salt) Basic information |
| | PPACKII (trifluoroacetate salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | crystalline solid | | color | White to off-white | | Stability: | Moisture Sensitive |
| | PPACKII (trifluoroacetate salt) Usage And Synthesis |
| Uses | Potent and specific irreversible inhibitor of plasma and glandular kallikreins. | | Biological Activity | ppackii is a specific and irreversible inhibitor of glandular and plasma kallikreins [1].human tissue kallikreins (hks) are a class of secreted serine proteases that involved in the release of vasodepressor peptides or kinins from a plasma substrate. kallikrein has diverse expression patterns and physiological roles. kallikrein has been primarily known as cancer biomarkers. kallikrein has been implicated in many cancer-related processes, such as cell-growth regulation, angiogenesis, invasion and metastasis. kallikrein could promote or inhibit neoplastic progression individually and/or with the interaction in cascades with other hks and proteases [2].ppackii prevented apolipoprotein proteolysis in dextran sulfate-precipitated human plasma ldl and inhibited serum atrial natriuretic peptide cleavage at micromolar concentrations [1]. it has been reported that ppackii inactivated the amidolytic activity of native human hageman factor (factor xii) at 5.3 μm [3]. | | references | [1]. byrne r e, scanu a m. apolipoprotein b-100 of plasma low density lipoproteins undergoes proteolysis by contact activation factors when plasma is treated with dextran sulfate-500-mgcl2[j]. journal of lipid research, 1989, 30(1): 109-120.
[2]. borgoo c a, diamandis e p. the emerging roles of human tissue kallikreins in cancer[j]. nature reviews cancer, 2004, 4(11): 876-890.
[3]. silverberg m, kaplan a p. enzymatic activities of activated and zymogen forms of human hageman factor (factor xii)[j]. blood, 1982, 60(1): 64-70. |
| | PPACKII (trifluoroacetate salt) Preparation Products And Raw materials |
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