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| | SB-756050 Basic information |
| Product Name: | SB-756050 | | Synonyms: | SB-756050;1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane;SB756050;SB 756050;SB-756050;SB-756050, >98%;1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-;G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19 | | CAS: | 447410-57-3 | | MF: | C21H28N2O8S2 | | MW: | 500.59 | | EINECS: | | | Product Categories: | | | Mol File: | 447410-57-3.mol |  |
| | SB-756050 Chemical Properties |
| Boiling point | 653.1±65.0 °C(Predicted) | | density | 1.328±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml | | form | A crystalline solid | | pka | -6.97±0.20(Predicted) | | color | White to off-white |
| | SB-756050 Usage And Synthesis |
| Description | SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50 = 1.3 μM for the human receptor). It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats. |
| | SB-756050 Preparation Products And Raw materials |
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