氯烯雌醚
| 中文名称 | 氯烯雌醚 |
|---|---|
| 中文同义词 | 氯代三(对甲氧基苯基)乙烯;氯烯雌醚;泰舒;氯烯雌酚;氯烯雌酚醚;三芳氯乙烯;跟踪,示踪,微量;氯三苯 |
| 英文名称 | CHLOROTRIANISENE |
| 英文同义词 | Anti-ADAM 17 (Cleaved-Arg215) antibody produced in rabbit;1,1',1''-(2-Chloro-1,1,2-ethenetriyl)tris(4-methoxybenzene);1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene);1,1',1(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene];1,1,1’’-(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxy-benzene];CHLOROTRIANISENE;chlorotris(4-methoxyphenyl)ethylene;Chlortrianisoestrol |
| CAS号 | 569-57-3 |
| 分子式 | C23H21ClO3 |
| 分子量 | 380.86 |
| EINECS号 | 209-318-6 |
| 相关类别 | 抑制剂;小分子抑制剂;小分子抑制剂，天然产物;试剂盒-Elisa试剂盒;有机化工原料;Inhibitors;API |
| Mol文件 | 569-57-3.mol |
| 结构式 |  |
氯烯雌醚 性质
| 熔点 | 114-116° |
|---|---|
| 沸点 | 496.07°C (rough estimate) |
| 密度 | 1.1010 (rough estimate) |
| 折射率 | 1.4585 (estimate) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 不溶于水；不溶于乙醇； DMSO 中≥16.1 mg/mL |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
| EPA化学物质信息 | Chlorotrianisene (569-57-3) |
| Target | Value |
|
Estrogen receptor
() |
Comparison of intracellular estrogen receptor (ER) affinities of Chlorotrianisene with respective rat uterine cytosolic ER affinities has initially suggested the potential for activation of ER as a mechanism of growth stimulation. Chlorotrianisene exhibits concentration dependent cell growth stimulation with an EC 50 of 28 nM and a K i of 500 nM in MCF-7 cells.
The incubation of Chlorotrianisene with rat liver microsomes and NADPH generates a reactive intermediate which binds covalently to proteins. Intermediate may inactivate the uterine estrogen receptors (ER). The incubation of Chlorotrianisene with rat liver microsomes and NADPH in the presence of rat uteri, under conditions which generate intermediate, markedly decreased the binding capacity of the ER for [ 3 H]estradiol (E2).
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | KV0600000 |
| 毒害物质数据 | 569-57-3(Hazardous Substances Data) |
| 提供商 | 语言 |
|---|---|
|
英文
|