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| | UK-371804 hydrochloride Basic information |
| Product Name: | UK-371804 hydrochloride | | Synonyms: | UK-371804 hydrochloride;UK-371804 HCl;UK-371,804 HCl >=98% (HPLC);2-((4-Chloro-1-guanidinoisoquinoline)-7-sulfonamido)-2-methylpropanoic acid hydrochloride;UK371804 HCl,UK 371804 HCl | | CAS: | 256476-36-5 | | MF: | C14H17Cl2N5O4S | | MW: | 422.28 | | EINECS: | | | Product Categories: | | | Mol File: | 256476-36-5.mol |  |
| | UK-371804 hydrochloride Chemical Properties |
| Melting point | 258 °C (decomp) | | storage temp. | -20°C | | solubility | DMSO: 42 mg/mL (99.46 mM);Ethanol: Insoluble | | form | powder | | color | white to beige | | Water Solubility | Water: Insoluble |
| | UK-371804 hydrochloride Usage And Synthesis |
| Biochem/physiol Actions | UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins. |
| | UK-371804 hydrochloride Preparation Products And Raw materials |
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