| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:MRT-83 hydrochloride
CAS:1359944-60-7
Package:2mg/RMB 594;100mg/RMB 9570
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MRT-83 hydrochloride manufacturers
- MRT-83 hydrochloride
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- $82.00 / 2mg
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2024-10-24
- CAS:1359944-60-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | MRT-83 hydrochloride Basic information |
| | MRT-83 hydrochloride Chemical Properties |
| storage temp. | 4°C, away from moisture | | solubility | DMSO : 250 mg/mL (434.74 mM; Need ultrasonic) | | form | Solid | | color | White to off-white |
| | MRT-83 hydrochloride Usage And Synthesis |
| Biological Activity | MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].
MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay[1]. | | References | [1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571. |
| | MRT-83 hydrochloride Preparation Products And Raw materials |
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