Log in | Join Free | china | japan | germany

GSK4027

Request For Quotation
GSK4027 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:GSK 4027
CAS:2079896-25-4
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:GSK 4027
CAS:2079896-25-4
Purity:98% Package:$130.9/5mg;$220.9/10mg;$450.9/25mg;$760.9/50mg;$1250.9/100mg;Bulk package Remarks:98%
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:GSK4027
CAS:2079896-25-4
Purity:95% Package:1G;10G;100G Remarks:GSK4027 is a potent and selective inhibitor of p300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) bromodomain (Ki = 1.4 nM; IC50 = 60 nM in a chromatin engagement assay).
Company Name: Hangzhou Synstar pharmaceutical Technology CO.,Ltd  
Tel: 0571-85361029
Email: synstar518@163.com
Products Intro: Product Name:GSK4027
CAS:2079896-25-4
Purity:98% Package:1g、5g、25g
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:GSK 4027
CAS:2079896-25-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
GSK4027 Basic information
Product Name:GSK4027
Synonyms:GSK4027;GSK4207;3(2H)-Pyridazinone, 4-bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenyl-3-piperidinyl]amino]-
CAS:2079896-25-4
MF:C17H21BrN4O
MW:377.28
EINECS:
Product Categories:
Mol File:2079896-25-4.mol
GSK4027 Structure
GSK4027 Chemical Properties
Boiling point 450.3±55.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:50.0(Max Conc. mg/mL);132.53(Max Conc. mM)
form A crystalline solid
pka9.58±0.10(Predicted)
Safety Information
MSDS Information
GSK4027 Usage And Synthesis
DescriptionGSK4027 is a potent and selective chemical probe for the PCAF/GCN5 bromodomain. GSK4027 has PCAF TR-FRET pIC50 = 7.4 ; PCAF BROMOscan pKi = 8.9; GCN5 BROMOscan pKi = 8.9; PCAF NanoBRET pIC50 =7.2; BRD4 BD1 TR-FRET pIC50 < 4.3. GSK4027 shows high potency for the PCAF/GCN5 bromodomain, high solubility, cellular target engagement, and ≥18000-fold selectivity over the BET family, together with ≥70-fold selectivity over the wider bromodomain families. p300/CREB binding protein associated factor (PCAF/KAT2B) and general control nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in retroviral infection, inflammation pathways, and cancer development.
in vitroHerein, this study reports GSK4027 as a chemical probe for the PCAF/GCN5 bromodomain, together with GSK4028 as an enantiomeric negative control._x000D_ _x000D_ Reference: J Med Chem. 2017 Jan 26;60(2):695-709. https://pubmed.ncbi.nlm.nih.gov/28002667/
targetGSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
GSK4027 Preparation Products And Raw materials
Tag:GSK4027(2079896-25-4) Related Product Information