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TCO-PEG12-NHS Ester

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TCO-PEG12-NHS Ester Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:TCO-PEG12-NHS ester
CAS:2185016-39-9
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Alfa Chemistry
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Email: Info@alfa-chemistry.com
Products Intro: Product Name:TCO-PEG12-NHS ester
CAS:2185016-39-9
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: +undefined18143011203
Email: info@chemextension.com
Products Intro: Product Name:TCO-PEG12-NHS ester
CAS:2185016-39-9
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
Company Name: Xian confluore Biological Technology Co., Ltd.
Tel: +86-15680926068 +86-15680926068
Email: 1924344760@confluore.cn
Products Intro: Product Name:(4E)-TCO-PEG12-NHS ester
CAS:2185016-39-9
Purity:>95.00% Package:250mg
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 18892239720
Email: psaitong@jm-bio.com
Products Intro: Product Name:TCO-PEG12-NHS ester
CAS:2185016-39-9
Package:100mg;250mg;500mg

TCO-PEG12-NHS Ester manufacturers
TCO-PEG12-NHS Ester Basic information
Product Name:TCO-PEG12-NHS Ester
Synonyms:TCO-PEG12-NHS Ester;5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 1-(4E)-4-cycloocten-1-yl 41-(2,5-dioxo-1-pyrrolidinyl) ester;(4E)-TCO-PEG12-NHS ester
CAS:2185016-39-9
MF:C40H70N2O18
MW:866.99
EINECS:
Product Categories:
Mol File:2185016-39-9.mol
TCO-PEG12-NHS Ester Structure
TCO-PEG12-NHS Ester Chemical Properties
density 1.20±0.1 g/cm3(Predicted)
solubility Soluble in DMSO, DCM, DMF
pka11.95±0.46(Predicted)
form Liquid
color Colorless to light yellow
Safety Information
MSDS Information
TCO-PEG12-NHS Ester Usage And Synthesis
DescriptionTCO-PEG12-NHS Ester is a water soluble PEG linker containing a TCO moiety and a NHS ester. PEG12 linear arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.
Biological ActivityTCO-PEG12-NHS ester is a PROTAC bridge and belongs to the PEG class.It can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

TCO-PEG12-NHS Ester Preparation Products And Raw materials
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