人肠抑素
中文名称 | 人肠抑素 |
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中文同义词 | 人肠抑素;人源肠抑素 |
英文名称 | ENTEROSTATIN, HUMAN |
英文同义词 | procolipase activation peptide;Enterostatin , mouse, rat);L-ALA-PRO-GLY-PRO-ARG SALT;ENTEROSTATIN, HUMAN;ENTEROSTATIN (HUMAN) ACETATE SALT;H-ALA-PRO-GLY-PRO-ARG-OH;H-ALA-PRO-GLY-PRO-ARG-OH ACETATE SALT;H-ALA-PRO-GLY-PRO-ARG-OH ACOH |
CAS号 | 117830-79-2 |
分子式 | C21H36N8O6 |
分子量 | 496.56 |
EINECS号 | |
相关类别 | 细胞信号和神经生物学;标准品;目录肽;目录多肽;Peptide;EnterostatinPeptides for Cell Biology;Other Obesity PeptidesObesity Research;Cytokines Growth Factors and Hormones (Obesity);Hormones;Obesity Peptides;Obesity Research;Other Obesity Research Products;Various Peptides |
Mol文件 | 117830-79-2.mol |
结构式 |
人肠抑素 性质
密度 | 1.54±0.1 g/cm3(Predicted) |
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储存条件 | −20°C |
溶解度 | 在无菌水中的溶解度为 0.70 mg/ml |
酸度系数(pKa) | 3.60±0.21(Predicted) |
形态 | 冻干固体。 |
颜色 | 白色至米白色 |
Human Endogenous Metabolite
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In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%).
Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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