| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Octyl-α-hydroxyglutarate
CAS:2097068-39-6
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
JW & Y Pharmlab Co., Ltd.
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| Tel: |
021-64340559 13651849907 |
| Email: |
xinyu_shi@jwypharmlab.com.cn |
| Products Intro: |
Product Name:2-Hydroxy-pentanedioic acid 1-octyl ester
CAS:2097068-39-6
Purity:0.97 Package:1g;5g;25g;100g;250g等可分装
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Octyl-α-hydroxyglutarate
CAS:2097068-39-6
|
|
| | 2-Hydroxy-pentanedioic acid 1-octyl ester Basic information |
| | 2-Hydroxy-pentanedioic acid 1-octyl ester Chemical Properties |
| Boiling point | 420.5±35.0 °C(Predicted) | | density | 1.088±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 5 mg/ml | | form | A crystalline solid | | pka | 4.45±0.10(Predicted) |
| | 2-Hydroxy-pentanedioic acid 1-octyl ester Usage And Synthesis |
| Description | α-Hydroxyglutaric acid (2-HG; ) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.1,2,3 Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.4,5 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.5,6,7 Octyl-α-hydroxyglutarate is a cell-permeable derivative of 2-HG. | | References | 1. Rzem, R., Veiga-da-Cunha, M., No?l, G., et al. A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria Proc. Natl. Acad. Sci. USA 101(48),16849-16854(2004).
2. Struys, E.A., Verhoeven, N.M., Roos, B., et al. Disease-related metabolites in culture medium of fibroblasts from patients with D-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria, and combined D/L-2-hydroxyglutaric aciduria Clin. Chem. 49(7),1133-1138(2003).
3. Struys, E.A., Salomons, G.S., Achouri, Y., et al. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria Am. J. Hum. Genet. 76(2),358-360(2005).
4. Ward, P., Patel, J., Wise, D.R., et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate Cancer Cell 17(3),225-234(2010).
5. Yang, H., Ye, D., Guan, K.L., et al. IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectives Clin. Cancer Res. 18(20),5562-5571(2012).
6. Xu, W., Yang, H., Liu, Y., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases Cancer Cell 19(1),17-30(2011).
7. Chowdhury, R., Yeoh, K.K., Tian, Y.M., et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases EMBO Rep. 12(5),463-469(2011). |
| | 2-Hydroxy-pentanedioic acid 1-octyl ester Preparation Products And Raw materials |
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