| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-O-GlcNAc Transferase (TI-14)
Purity:IgG fraction of antiserum, buffered aqueous solution Package:200μL Remarks:O6014
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| | ANTI-OGT Basic information |
| Product Name: | ANTI-OGT | | Synonyms: | ANTI-O-GLCNAC TRANSFERASE (DM-17);ANTI-O-GLCNAC TRANSFERASE (SQ-17);ANTI-O-GLCNAC TRANSFERASE (TI-14);ANTI-OGT;ANTI-O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE;Anti-O-GlcNAc Transferase (TI-14) antibody produced in rabbit;Anti-O-GlcNAc Transferase (DM-17) antibody produced in rabbit;Anti-O-linked N-Acetylglucosamine Transferase, Anti-OGT | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-OGT Structure]() |
| | ANTI-OGT Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| Hazard Codes | Xn | | Risk Statements | 21/22 | | Safety Statements | 36/37 | | WGK Germany | 3 |
| | ANTI-OGT Usage And Synthesis |
| Uses | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper) | | Uses | Anti-O-GlcNAc Transferase (DM-17) antibody produced in rabbit has been used for Western Blotting. | | General Description | O-GlcNAc transferase (OGT) catalyzes the addition of an N-acetylglucosamine residue to the amino acids serine or threonine. The enzyme is an homotrimer consisting of three subunits of 110 kDa each, with multiple tetratricopeptide (TPR) repeats. | | Biochem/physiol Actions | O-linked β-N-acetyl glycosamine (O-GlcNAc) is involved in repressing transcription. O-GlcNAc transferase (OGT) interacts with a histone deacetylase complex by binding to the co repressor Sin3A. This interaction leads to the repression of transcription, after transcription factors and RNA polymerase II are modified by addition of O-GlcNAc. O-GlcNAc modification reversibly inhibits proteosomal function in an ubiquitin-independent fashion. |
| | ANTI-OGT Preparation Products And Raw materials |
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