| Company Name: |
GL Biochem (Shanghai) Ltd
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| Tel: |
21-61263452 13641803416 |
| Email: |
ymbetter@glbiochem.com |
| Products Intro: |
Product Name:rec Glial Cell Line-Derived Neurotrophic Factor (human)
Purity:95% HPLC,98% HPLC Package:10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:rec Glial Cell Line-Derived Neurotrophic Factor (huMan); ;rec GDNF (huMan), rec Astrocyte-Derived Trophic Factor 1 (huMan), rec ATF-1 (huMan)
Purity:99% Package:2.0μg
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:GDNF
Purity:>=98% (HPLC); >=98% (SDS-PAGE) Package:10μg Remarks:SRP3200
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| | GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Basic information |
| Product Name: | GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN | | Synonyms: | HUMAN GDNF;RECOMBINANT HUMAN GDNF;HUMAN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR;HUMAN GLIAL-DERIVED NEUROTROPHIC FACTOR;HUMAN ATF-1;GDNF;GDNF (GLIAL DERIVED NEUROTROPIC FACTOR), HUMAN;GDNF HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Structure]() |
| | GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder | | color | white |
| | GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Usage And Synthesis |
| Uses | Glial cell line-derived neurotrophic factor human (GDNF) has been used as a component in the neurobasal medium for neural differentiation. It has also been used for self-renewal, expansion and differentiation of?spermatogonial stem cells (SSCs). | | General Description | Glial cell line-derived neurotrophic factor (GDNF) human gene is located on human chromosome 5p13.2. | | Biochem/physiol Actions | Glial Cell Line-Derived Neurotrophic Factor is a member of the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF is founding member of the GDNF family of ligands, which to date include GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). GDNF is a glycosylated disulfide-linked homodimeric protein of ~15 kDa. Mature rat and human GDNF share ~93% sequence homology, with strong species cross-reactivity. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using the Parkinson′s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. GDNF promotes survival of various neuronal cells in central and peripheral nervous systems and different stages of development, including motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. In addition, exogenously applied GDNF has been shown to rescue damaged facial motor neurons in vivo. |
| | GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Preparation Products And Raw materials |
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