| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 18892239720 |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:Calcimycin hemimagnesium
CAS:72124-77-7
Purity:98% Package:1mg
|
| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:Calcimycin hemimagnesium
CAS:72124-77-7
Purity:98% Package:1mg
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.com |
| Products Intro: |
Product Name:Calcimycin hemimagnesium
CAS:72124-77-7
|
|
| | CALCIMYCIN A23187 HEMIMAGNESIUM SALT Basic information |
| Product Name: | CALCIMYCIN A23187 HEMIMAGNESIUM SALT | | Synonyms: | CALCIMYCIN A23187 HEMIMAGNESIUM SALT;CALCIMYCIN HEMIMAGNESIUM SALT;CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT;calcium ionophore A23187 hemimagnesium;CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT BIOCHEMIKA;a23187hemimagnesium salt;A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt;Calcimycin hemimagnesium | | CAS: | 72124-77-7 | | MF: | C58H72MgN6O12 | | MW: | 1069.55 | | EINECS: | | | Product Categories: | | | Mol File: | 72124-77-7.mol |  |
| | CALCIMYCIN A23187 HEMIMAGNESIUM SALT Chemical Properties |
| storage temp. | 2-8°C | | solubility | acetone: 5 mg/mL, clear, faintly yellow | | BRN | 6765085 |
| | CALCIMYCIN A23187 HEMIMAGNESIUM SALT Usage And Synthesis |
| Uses | Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4]. | | in vivo | Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5]. | Animal Model: | Mice (ICR, 25-30 g)[5] | | Dosage: | 2.5 or 7.5 nM | | Administration: | Intrapleurally | | Result: | Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
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| | References | [1] Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. DOI:10.1128/AAC.01130-10
[2] Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. DOI:10.1038/sj.embor.embor722
[3] Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. DOI:10.4161/auto.25900
[4] Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200. DOI:10.1016/j.bbagen.2017.09.010
[5] Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5. DOI:10.1007/BF00180016 |
| | CALCIMYCIN A23187 HEMIMAGNESIUM SALT Preparation Products And Raw materials |
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