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| | CASPASE INHIBITOR3 Basic information |
| Product Name: | CASPASE INHIBITOR3 | | Synonyms: | CASPASE INHIBITOR3;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;N-BOC-D-FMK;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone | | CAS: | 187389-53-3 | | MF: | C11H18FNO5 | | MW: | 263.26 | | EINECS: | | | Product Categories: | Caspase/Related Products;Apoptosis | | Mol File: | 187389-53-3.mol |  |
| | CASPASE INHIBITOR3 Chemical Properties |
| Boiling point | 383.5±37.0 °C(Predicted) | | density | 1.150±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | -20°C | | solubility | Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C. | | pka | 10.12±0.46(Predicted) | | form | Powder | | color | Off-white |
| | CASPASE INHIBITOR3 Usage And Synthesis |
| Uses | N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications. | | Uses | Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites . | | Biochem/physiol Actions | Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10. |
| | CASPASE INHIBITOR3 Preparation Products And Raw materials |
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