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| | ANTI-TDT Basic information |
| Product Name: | ANTI-TDT | | Synonyms: | ANTI-TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE;ANTI-TERMINAL TRANSFERASE;ANTI-TERMINAL TRANSFERASE, (6A6.009);ANTI-TDT, HUMAN;ANTI-TDT (TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE);ANTI-TDT;ANTI-TDT (6A6.009);ANTI-HUMAN TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-TDT Structure]() |
| | ANTI-TDT Chemical Properties |
| storage temp. | 2-8°C | | form | buffered aqueous solution |
| | ANTI-TDT Usage And Synthesis |
| General Description | This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3′-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. (provided by RefSeq) | | Biochem/physiol Actions | DNTT is the template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5′-triphosphate to the 3′-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3′-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. |
| | ANTI-TDT Preparation Products And Raw materials |
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