RG-13022
中文名称 | RG-13022 |
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中文同义词 | 酪氨酸磷酸化抑制剂RG 13022;TYROSINE KINASE抑制剂(RG13022);化合物RG 13022;3-(3,4-二甲氧基苯基)-2-(吡啶-3-基)丙烯腈 |
英文名称 | TYRPHOSTIN RG 13022 |
英文同义词 | 3-(3,4-Dimethoxyphenyl)-2-(3-pyridinyl)propenenitrile;α-(3-Pyridyl)-3,4-dimethoxybenzeneacrylonitrile;3-(3,4-dimethoxyphenyl)-2-(pyridin-3-yl)acrylonitrile;3-Pyridineacetonitrile,a-[(3,4-dimethoxyphenyl)methylene]-;ALPHA-(3'-PYRIDYL)-(3,4-DIMETHOXY)CINNAMONITRILE;RG-13022;TYRPHOSTIN RG 13022;2-(3,4'-DIMETHOXYPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE |
CAS号 | 136831-48-6 |
分子式 | C16H14N2O2 |
分子量 | 266.29 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 136831-48-6.mol |
结构式 | ![]() |
RG-13022 性质
熔点 | 116.0 to 120.0 °C |
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沸点 | 423.8±45.0 °C(Predicted) |
密度 | 1.172±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,2-8°C |
溶解度 | 可溶于DMSO或乙醇:可溶 |
酸度系数(pKa) | 3.03±0.12(Predicted) |
形态 | 白色固体。 |
颜色 | 白色到黄色到绿色 |
Target | Value |
EGFR
(Cell-free assay) | 4 μM |
RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC 50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC 50 s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively. RG-13022 inhibits not only EGF-induced growth but also growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. RG-13022 also totally blocks estrogen-stimulated phosphorylation of the EGF receptor, as well as estrogen-induced cell proliferation, suggesting that functioning TK pathways are required for estrogen action.
RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
海关编码 | 2933.39.9200 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101429 | RG-13022 RG13022 | 136831-48-6 | 2mg | 400元 |
2024/04/30 | HY-101429 | RG-13022 RG13022 | 136831-48-6 | 5mg | 560元 |