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| | 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Basic information |
| | 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Chemical Properties |
| density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:125.0(Max Conc. mg/mL);472.29(Max Conc. mM) | | form | Solid | | pka | 9.16±0.10(Predicted) | | color | Pink to orange |
| | 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Usage And Synthesis |
| Description | L82-G17 is a selective uncompetitive inhibitor of DNA ligase I (LigI). | | Uses | 3-Hydroxy-benzaldehyde (5-Chloro-6-oxo-1,6-dihydro-pyridazin-4-yl)-hydrazone can be used to determine the structure-activity relationships among DNA ligase inhibitors. | | in vitro | Among the LigI-selective inhibitors, L82-G17 exhibited increased activity against and selectivity for LigI compared with L82. Notably. L82-G17 is an uncompetitive inhibitor of the third step of the ligation reaction, phosphodiester bond formation. Cells expressing LigI were more sensitive to L82-G17 than isogenic LIG1 null cells._x000D_
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Reference: DNA Repair (Amst). 2017 Dec;60:29-39. https://pubmed.ncbi.nlm.nih.gov/29078112/ | | target | L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. |
| | 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Preparation Products And Raw materials |
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