化合物SGN-2FF
中文名称 | 化合物SGN-2FF |
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中文同义词 | 化合物SGN-2FF;(3S,4R,5S,6S)-3-氟-6-甲基四氢-2H-吡喃-2,4,5-三醇;REL-(3S,4R,5S,6S)-3-氟-6-甲基四氢-2H-吡喃-2,4,5-三醇 |
英文名称 | SGN-2FF |
英文同义词 | SGN-2FF;2-fluorofucose( SGN-2FF);SGN-2FF,SGN 2FF,inhibit,SGN2FF,Inhibitor;rel-(3S,4R,5S,6S)-3-Fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triol |
CAS号 | 2089647-47-0 |
分子式 | C6H11FO4 |
分子量 | 166.15 |
EINECS号 | |
相关类别 | |
Mol文件 | 2089647-47-0.mol |
结构式 |
化合物SGN-2FF 性质
沸点 | 323.7±42.0 °C(Predicted) |
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密度 | 1.42±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C,protect from light |
形态 | 固体 |
酸度系数(pKa) | 11?+-.0.70(Predicted) |
颜色 | 白色至米白色 |
水溶解性 | Water : 36.67 mg/mL (220.70 mM) |
Fucosyltransferase
SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.
SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-107366 | 化合物SGN-2FF SGN-2FF | 2089647-47-0 | 5mg | 1500元 |
2024/08/19 | HY-107366 | 化合物SGN-2FF SGN-2FF | 2089647-47-0 | 10mg | 2400元 |