1202710-57-3
| 中文名称 | 1202710-57-3 |
|---|---|
| 中文同义词 | 化合物 T11504;GSTO 抑制剂 2 |
| 英文名称 | GSTO-IN-2 |
| 英文同义词 | GSTO-IN-2;GSTO inhibitor 2;L-Aspartic acid, L-γ-glutamyl-, 21-[(3α,5β)-23-carboxy-24-norcholan-3-yl] ester;GSTOIN2,GSTO IN 2 |
| CAS号 | 1202710-57-3 |
| 分子式 | C33H52N2O9 |
| 分子量 | 620.78 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1202710-57-3.mol |
| 结构式 |  |
1202710-57-3 性质
| 沸点 | 821.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 2.21±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
GSTO-IN-2是一种谷胱甘肽S-转移酶 (glutathione S-transferase) 抑制剂，对于GSTA2，GSTM1和GSTP1-1的 IC50 值分别为3.6，16.3，1.4 μM。
IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)
GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231..
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-112534 | GSTO-IN-2 | 1 mg | 2200元 | |
| 2024/08/19 | HY-112534 | 1202710-57-3 GSTO-IN-2 | 1202710-57-3 | 5mg | 5500元 |