| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Axitinib-13C-d3
CAS:1261432-00-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Manhag Testing Technology Co., Ltd
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| Tel: |
020-020-3846236 17688849268 |
| Email: |
2443244976@qq.com |
| Products Intro: |
Product Name:Axitinib-[13C,d3]
CAS:1261432-00-1
Purity:1mg Package:1mg
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| | Axitinib-13C-d3 Basic information |
| Product Name: | Axitinib-13C-d3 | | Synonyms: | Axitinib-13C-d3;[13C,2H3]-Axitinib;(E)-N-(methyl-13C-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide | | CAS: | 1261432-00-1 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Axitinib-13C-d3 Structure]() |
| | Axitinib-13C-d3 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | color | White to off-white |
| | Axitinib-13C-d3 Usage And Synthesis |
| Description | Axitinib-13C-d3 is intended for use as an internal standard for the quantification of axitinib by GC- or LC-MS. Axitinib is a VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively). It also inhibits c-Kit and PDGFRβ (IC50s = 1.7 and 1.6 nM, respectively). It inhibits VEGF-induced migration of and tube formation by human umbilical vein endothelial cells (HUVECs). Axitinib (1-100 mg/kg) reduces microvessel density, a marker of angiogenesis, and tumor growth in MV522 colon carcinoma, A375 melanoma, SN12C-GFP renal carcinoma, and U87 glioma mouse xenograft models in a dose-dependent manner. Formulations containing axitinib have been used in the treatment of renal cell carcinoma. |
| | Axitinib-13C-d3 Preparation Products And Raw materials |
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