| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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sales@dcchemicals.com |
| Products Intro: |
Product Name:(E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide
CAS:324579-65-9
Purity:98% HPLC Package:100mg，250mg，1g
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| | inh-02
(RNF5 inhibitor inh-02) Basic information |
| Product Name: | inh-02
(RNF5 inhibitor inh-02) | | Synonyms: | inh-02
(RNF5 inhibitor inh-02);Benzenecarboximidamide, N-[3-methyl-4-(phenylmethyl)-1,2,4-thiadiazol-5(4H)-ylidene]-N'-phenyl-;RNF5 inhibitor Inh-2;RNF5 inhibitor Inh-2 (E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide;RNF5 inhibitor inh-02;RNF-5 inhibitor inh-02,RNF5 inhibitor inh02,RNF5 inhibitor inh 02;(E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N"-phenylbenzimidamide;RNF5-IN-2 | | CAS: | 324579-65-9 | | MF: | C23H20N4S | | MW: | 384.5 | | EINECS: | | | Product Categories: | | | Mol File: | 324579-65-9.mol |  |
| | inh-02
(RNF5 inhibitor inh-02) Chemical Properties |
| form | Solid | | color | White to yellow |
| | inh-02
(RNF5 inhibitor inh-02) Usage And Synthesis |
| Biological Activity | RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research[1]. | | References | [1]. Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8. |
| | inh-02
(RNF5 inhibitor inh-02) Preparation Products And Raw materials |
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