| Company Name: |
Tianjin Anhao Biological Technology Co., Ltd.
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| Tel: |
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| Email: |
sales@ahpharmatech.com |
| Products Intro: |
Product Name:(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one
CAS:133812-16-5
Purity:97% Package:1g; 5g; 25g; 1kg; 25kg Remarks:X-3093
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| Company Name: |
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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| Tel: |
025-66113011 18112977050 |
| Email: |
cb6@aikonchem.com |
| Products Intro: |
Product Name:(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one
CAS:133812-16-5
Purity:95+% Package:1g;5g;10g
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| | (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Basic information |
| Product Name: | (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& | | Synonyms: | (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&;4-benzyl-3-crotonyl-2-oxazolidinone;Locostatin;(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%;(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one;Cell Sheet Migration Inhibitor, Locostatin;(E/Z)-Locostatin;2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)- | | CAS: | 133812-16-5 | | MF: | C14H15NO3 | | MW: | 245.27 | | EINECS: | | | Product Categories: | | | Mol File: | 133812-16-5.mol |  |
| | (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Chemical Properties |
| Melting point | 84-88 °C(lit.) | | Boiling point | 351.0±25.0 °C(Predicted) | | density | 1.205±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (60 mg/ml) | | form | solid | | pka | -1?+-.0.40(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Usage And Synthesis |
| Description | Locostatin (133812-16-5) inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3? Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5 | | Uses | Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration | | References | Zhu et al. (2005), A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration; Chem. Biol., 12 981
Beshir et al. (2011), Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket; For. Immunopathol. Dis. Therap. 2 47
Menoret et al. (2009), The oxazolidinone derivative locostatin induces cytokine appeasement; J. Immunol. 183 7489
Ma et al. (2019), Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice; Dig. Dis. Sci. 64 2570
Mc Henry et al. (2008), Raf kinase inhibitor protein positively regulates cell-cell adhesion; J. Cell Biochem. 103 972 |
| | (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Preparation Products And Raw materials |
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