PF-05085727
| 中文名称 | PF-05085727 |
|---|---|
| 中文同义词 | 4-(氮杂环丁烷-1-基)-1-甲基-3-(1-甲基-5-(4-(三氟甲基)苯基)-1H-吡唑-4-基)-1H-吡唑并[3,4-D]嘧啶;化合物 T16482;化合物 PF-05085727 |
| 英文名称 | PF-05085727 |
| 英文同义词 | PF-05085727;4-(AZETIDIN-1-YL)-1-METHYL-3-(1-METHYL-5-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOL-4-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE;1H-Pyrazolo[3,4-d]pyrimidine, 4-(1-azetidinyl)-1-methyl-3-[1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-;PF-05085727 >=98% (HPLC);PF05085727,PF 05085727 |
| CAS号 | 1415637-72-7 |
| 分子式 | C??H??F?N? |
| 分子量 | 413.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1415637-72-7.mol |
| 结构式 |  |
PF-05085727 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：62.5 mg/mL（151.19 mM；需要超声波） |
| 形态 | 固体 |
| 颜色 | 白色至黄色 |
|
PDE2A 2 nM (IC 50 ) |
PF-05085727 shows weak activity with IC 50 of 162 μM to induce cell death in a cellular toxicity assay using transformed human liver endothelial (THLE) cells.PF-05085727 (3 μM) shows a minimal inhibition of cytochrome P450 enzymes (CYPs), inhibits 1A2, 2C8, 2C9, 2D6 and 3A4 with percentage% of 16%, 18%, 7%, 4%, and 30%, respectively.PF-05085727 (10 μM) inhibits PDE1B, PDE4B, PDE7B and PDE10A with IC 50 values of 12.146 μM, 22,503 μM, 13.157 μM and 6.515 μM, respectively.
PF-05085727 (subcutaneous injection; 3.2 mg/kg/mice; 3 mg/kg/rat) gives a ratio of unbound brain (C bu ) to unbound plasma (C pu ) of ca. 0.27 and 0.37, respectively.PF-05085727 in mice leads to an acute and exposure-dependent elevation in the accumulation of bulk levels of cGMP in cortex, striatum, and hippocampus as measured by enzyme-linked immunosorbent assay.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-102050 | PF-05085727 PF-05085727 | 1415637-72-7 | 5mg | 800元 |
| 2024/08/19 | HY-102050 | PF-05085727 PF-05085727 | 1415637-72-7 | 10mM * 1mLin DMSO | 880元 |