RIPK1-IN-7
中文名称 | RIPK1-IN-7 |
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中文同义词 | 化合物RIPK1-IN-7;1-(5-(4-氨基-7-乙基-7H-吡咯并[2,3-D]嘧啶-5-基)吲哚啉-1-基)-2-(3-(三氟甲氧基)苯基)乙酮 |
英文名称 | RIPK1-IN-7 |
英文同义词 | RIPK1-IN-7;RIPK1 inhibitor 7;Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]-;RIPK-1-IN-7,inhibit,TrkA,Mer,Receptor-interacting protein kinases,Flt4,Axl,TrkB,Inhibitor,RIP kinase,RIPK,TrkC,RIPK1 IN 7,RIPK1IN7,HRI;1-(5-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one |
CAS号 | 2300982-44-7 |
分子式 | C25H22F3N5O2 |
分子量 | 481.47 |
EINECS号 | |
相关类别 | |
Mol文件 | 2300982-44-7.mol |
结构式 | ![]() |
RIPK1-IN-7 性质
沸点 | 724.8±60.0 °C(Predicted) |
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密度 | 1.42±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:62.5mg/mL(129.81mM);水:< 0.1 mg/mL(不溶) |
形态 | 固体 |
酸度系数(pKa) | 5.76±0.30(Predicted) |
颜色 | 浅黄至黄色 |
RIPK1-IN-7 是受体相互作用蛋白激酶 1 (RIPK1) 抑制剂,Kd 值为 4 nM,IC50 值为 11 nM。RIPK1-IN-7 在 实验性 B16 黑色素瘤肺转移模型中具有良好的抗转移活性。
IC50: 11 nM (RIPK1)
Kd: 4 nM (RIPK1)
RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC
50
of 2nM.
RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC
50
s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-119933 | RIPK1-IN-7 | 1 mg | 1714元 | |
2024/04/30 | HY-119933 | RIPK1-IN-7 RIPK1-IN-7 | 2300982-44-7 | 5mg | 3400元 |