| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:SNIPER(BRD)-1
CAS:2095244-54-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:SNIPER(BRD)-1
CAS:2095244-54-3
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more
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| | SNIPER(BRD)-1 Basic information |
| Product Name: | SNIPER(BRD)-1 | | Synonyms: | SNIPER(BRD)-1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-α-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2,3,9-trimethyl-, (6S)- | | CAS: | 2095244-54-3 | | MF: | C53H66ClN9O8S2 | | MW: | 1056.74 | | EINECS: | | | Product Categories: | | | Mol File: | 2095244-54-3.mol |  |
| | SNIPER(BRD)-1 Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, stored under nitrogen | | solubility | DMSO : 100 mg/mL (94.63 mM; Need ultrasonic) | | form | Solid | | pka | 14.25±0.46(Predicted) | | color | Off-white to light yellow |
| | SNIPER(BRD)-1 Usage And Synthesis |
| Biological Activity | SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1]. | | References | [1]. Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209. |
| | SNIPER(BRD)-1 Preparation Products And Raw materials |
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