RO-7
| 中文名称 | RO-7 |
|---|---|
| 中文同义词 | 化合物 T12743 |
| 英文名称 | RO-7 |
| 英文同义词 | RO-7;1H-Pyrido[2,1-f][1,2,4]triazine-4,6-dione, 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-2,3-dihydro-5-hydroxy-3-[(1R)-2,2,2-trifluoro-1-methylethyl]-;RO 7,RO7 |
| CAS号 | 1370241-45-4 |
| 分子式 | C24H20F3N3O3S |
| 分子量 | 487.49 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1370241-45-4.mol |
| 结构式 |  |
RO-7 性质
| 沸点 | 594.1±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.50±1.00(Predicted) |
RO-7 是甲型和乙型流感病毒的二代聚合酶 PA 亚基内切核酸酶抑制剂。
RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses.
RO-7 protects mice from lethal challenge with both influenza A and B viruses.