AS2863619 free base
| 中文名称 | AS2863619 free base |
|---|---|
| 中文同义词 | 化合物 T10382;化合物 AS2863619 FREE BASE |
| 英文名称 | AS2863619 free base |
| 英文同义词 | AS2863619 free base;1,2,5-Oxadiazol-3-amine, 4-[1-(2-methyl-1H-benzimidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-;AS-2863619 free base,AS2863619 free base |
| CAS号 | 2241300-50-3 |
| 分子式 | C16H12N8O |
| 分子量 | 332.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2241300-50-3.mol |
| 结构式 |  |
AS2863619 free base 性质
| 沸点 | 755.8±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.75±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/ml（752.29 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.44±0.10(Predicted) |
| 颜色 | 白色至米白色 |
|
CDK8 0.61 nM (IC 50 ) |
CDK19 4.28 nM (IC 50 ) |
GSK3α 76.67 nM (IC 50 ) |
GSK3β 63.06 nM (IC 50 ) |
STAT5
|
AS2863619 (1 μM; 22 hours; mouse CD4 + T cells) treatment suppresses serine phosphorylation of the PSP motif of STAT5b to ~40% while enhancing tyrosine phosphorylation in the C-terminal domain to ~160% of control-treated samples.
Western Blot Analysis
| Cell Line: | Mouse CD4 + T cells |
| Concentration: | 1 μM |
| Incubation Time: | 22 hours |
| Result: | Suppressed serine phosphorylation of the PSP motif of STAT5b to ~40% while enhancing tyrosine phosphorylation in the C-terminal domain to ~160% of control-treated samples. |
AS2863619 (30 mg/kg; oral administration; daily; for 2 weeks; mice) treatment after sensitization with 2,4-dinitrofluorobenzene (DNFB) dampens the degree of the secondary response, with milder infiltration of inflammatory cells into the skin and decreases ratios of interferon-γ + (IFN-γ + ) cells in a skin contact hypersensitivity model, when compared with vehicle-treated control mice. T reg depletion before the elicitation of the secondary response abolishes AS2863619-induced suppression. KLRG1 + Foxp3 + T cells are specifically increased in DNFB sensitized AS2863619-treated mice.
| Animal Model: | Mice with DNFB-induced contact skin hypersensitivity |
| Dosage: | 30 mg/kg |
| Administration: | Oral administration; daily; for 2 weeks |
| Result: | The degree of the secondary response, with milder infiltration of inflammatory cells into the skin and decreased ratios of interferon-γ + (IFN-γ + ) cells. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-126675 | AS2863619 free base | 1 mg | 1409元 | |
| 2024/08/19 | HY-126675 | AS2863619 free base AS2863619 free base | 2241300-50-3 | 5mg | 3100元 |