CS-003 Free base

CS-003 Free base Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:CS-003 Free base
CAS:191672-52-3
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Email: liming@bio-fount.com
Products Intro: Product Name:CS-003 Free base
CAS:191672-52-3
Purity:97.0% Package:5mg
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Products Intro: Product Name:CS-003 Free base
CAS:191672-52-3
Purity:98% Package:5mg;10mg;20mg;50mg;100mg;200mg
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840
Email: psaitong@jm-bio.com
Products Intro: Product Name:CS-003 Free base
CAS:191672-52-3
Package:1mg;5mg Remarks: 试剂级
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:CS-003 Free base;CS 003 Free base,CS003 Free base
CAS:191672-52-3
Purity:98% Package:5 mg
CS-003 Free base Basic information
Product Name:CS-003 Free base
Synonyms:CS-003 Free base;Methanone, [(2R)-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2-oxidospiro[benzo[c]thiophene-1(3H),4'-piperidin]-1'-yl]ethyl]-4-morpholinyl](3,4,5-trimethoxyphenyl)-;CS 003 Free base,CS003 Free base
CAS:191672-52-3
MF:C34H38Cl2N2O6S
MW:673.65
EINECS:
Product Categories:
Mol File:191672-52-3.mol
CS-003 Free base Structure
CS-003 Free base Chemical Properties
Boiling point 846.5±65.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka8.69±0.20(Predicted)
Safety Information
MSDS Information
CS-003 Free base Usage And Synthesis
Biological ActivityCS-003 Free base (CS-003) is a tritachykinin receptor antagonist with high affinity for human neurokinin NK1, NK2 and NK3 receptors with Ki values of 2.3 nM and 0.54 nM, respectively and 0.74 nM.It can be used in the study of neurokinin-related respiratory diseases.
in vitro

CS-003 (0.01-10 μM; 24 hours) inhibits NK1, NK2 or NK3 induced inositol phosphate formation in a concentration-dependent manner with pA2 values of 8.7, 9.4 and 9.5 μM, respectively.

in vivo

CS-003 (intravenous injection; 0.01-3.0 mg/kg; 5 min before neurokinin A/B/C injection) inhibits substance P-induced tracheal vascular hyperpermeability, neurokinin A- and neurokinin B-induced bronchoconstriction with ID 50 values of 0.13, 0.040 and 0.063 mg/kg, respectively.

target< /table>

NK1

2.3 nM (Ki)

NK2

0.54 nM (Ki)

NK3

0.74 nM (Ki)

CS-003 Free base Preparation Products And Raw materials
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