BMS-1001
| 中文名称 | BMS-1001 |
|---|---|
| 中文同义词 | 化合物BMS-1001 HYDROCHLORIDE;(R)-2-((2-((3-氰基苄基)氧基)-4-((3-(2,3-二氢苯并[B][1,4]二氧杂环己烯-6-基)-2-甲基苄基) 氧基)-5-甲基苄基)氨基)-3-羟基丙酸盐酸盐;BMS-1001(盐酸盐);N-[[2-[(3-氰基苯基)甲氧基]-4-[[3-(2,3-二氢-1,4-苯并二氧杂环己烷-6-基)-2-甲基苯基]甲氧基]-5-甲基苯基]甲基]-D-丝氨酸盐酸盐 |
| 英文名称 | BMS-1001 |
| 英文同义词 | BMS-1001 hydrochloride (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5- methylbenzyl)-D-serine hydrochloride;(2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride;Inhibitor,BMS 1001,inhibit,ICB,toxicity,BMS1001,immune,checkpoint,BMS 1001 hydrochloride,BMS-1001,BMS1001 hydrochloride,low |
| CAS号 | 2113650-04-5 |
| 分子式 | C35H35ClN2O7 |
| 分子量 | 631.12 |
| EINECS号 | |
| 相关类别 | 抑制剂 |
| Mol文件 | 2113650-04-5.mol |
| 结构式 |  |
BMS-1001 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形态 | 结晶固体 |
| 颜色 | 白色至米白色 |
BMS-1001 hydrochloride 是具有口服活性的、人 PD-L1/PD-1 免疫检查点的抑制剂。BMS-1001 hydrochloride 具有细胞毒性低的特点。
PD-L1/PD-1.
BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.