2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)-
| 中文名称 | 2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)- |
|---|---|
| 中文同义词 | 化合物 T30451;1-(4,6-二甲氧基苯并[D][1,3]二氧杂环戊烷-5-基)-2-(2-羟基苯基)丙-2-烯-1-酮 |
| 英文名称 | 2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)- |
| 英文同义词 | 2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)-;Biliatresone |
| CAS号 | 1801433-90-8 |
| 分子式 | C18H16O6 |
| 分子量 | 328.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1801433-90-8.mol |
| 结构式 |  |
2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)- 性质
| 沸点 | 559.6±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.301±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.05±0.35(Predicted) |
| 形态 | 粘稠液体 |
| 颜色 | 白色至黄色 |
Biliatresone has a reduction in primary cilia and a dose-dependent decrease in visible microtubules, suggesting that Biliatresone decreases microtubule stability in primary neonatal mouse extrahepatic cholangiocytes.
Biliatresone (2 µg/ml; for 24 hours) shows disruption of the spheroid lumen and abnormal cholangiocyte polarity in mouse cholangiocyte.
Biliatresone exhibits toxicity at doses of 0.065-1.0 μg/mL with a marked reduction and the lethal dose of Biliatresone in a zebrafish assay is 1 μg/mL.
Larvae treated at 5 dpf with low doses of biliatresone [0.0625 µg/ml (0.2 µM) and 0.125 µg/ml (0.4 µM)] shows only subtle gallbladder defects, whereas larvae treated with higher doses has pronounced morphological defects of the gallbladder and extrahepatic ducts.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-119412 | 2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)- Biliatresone | 1801433-90-8 | 5mg | 3800元 |
| 2024/04/30 | HY-119412 | 2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)- Biliatresone | 1801433-90-8 | 10mg | 6000元 |