Company Name: |
ChemeGen 中国
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Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:SHS4121705 CAS:2379550-82-8 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:SHS4121705;SHS4121705,SHS-4121705 CAS:2379550-82-8 Purity:98% Package:50 mg
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Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
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Tel: |
025-58851786 17714337195 |
Email: |
sales@tybiochem.com |
Products Intro: |
Product Name:6-[[4-(trifluoromethoxy)phenyl]amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(3H)-one CAS:2379550-82-8 Purity:95+% Package:1g;5g
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Company Name: |
Cayman Chemical Company
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Tel: |
(800) 364-9897 |
Email: |
cayman@caymanchem.com |
Products Intro: |
Product Name:SHS4121705 CAS:2379550-82-8
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| SHS4121705 Basic information |
Product Name: | SHS4121705 | Synonyms: | SHS4121705;SHS4121705,SHS-4121705;[1,2,5]Oxadiazolo[3,4-b]pyrazin-5(3H)-one, 6-[[4-(trifluoromethoxy)phenyl]amino]-;6-[[4-(trifluoromethoxy)phenyl]amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(3H)-one | CAS: | 2379550-82-8 | MF: | C11H6F3N5O3 | MW: | 313.19 | EINECS: | | Product Categories: | | Mol File: | 2379550-82-8.mol | ![SHS4121705 Structure](CAS/20210111/GIF/2379550-82-8.gif) |
| SHS4121705 Chemical Properties |
Boiling point | 338.3±52.0 °C(Predicted) | density | 1.81±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 10 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml | form | A crystalline solid | pka | -2.30±0.20(Predicted) |
| SHS4121705 Usage And Synthesis |
Biological Activity | SHS4121705 is an orally bioavailable mitochondrial uncoupler.1 It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH). | References | 1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020) |
| SHS4121705 Preparation Products And Raw materials |
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