| Company Name: |
ChemeGen 中国
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:SHS4121705
CAS:2379550-82-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:SHS4121705;SHS4121705,SHS-4121705
CAS:2379550-82-8
Purity:98% Package:50 mg
|
| Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
|
| Tel: |
025-58851786 17714337195 |
| Email: |
sales@tybiochem.com |
| Products Intro: |
Product Name:6-[[4-(trifluoromethoxy)phenyl]amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(3H)-one
CAS:2379550-82-8
Purity:95+% Package:1g;5g
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:SHS4121705
CAS:2379550-82-8
|
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| | SHS4121705 Basic information |
| Product Name: | SHS4121705 | | Synonyms: | SHS4121705;SHS4121705,SHS-4121705;[1,2,5]Oxadiazolo[3,4-b]pyrazin-5(3H)-one, 6-[[4-(trifluoromethoxy)phenyl]amino]-;6-[[4-(trifluoromethoxy)phenyl]amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(3H)-one | | CAS: | 2379550-82-8 | | MF: | C11H6F3N5O3 | | MW: | 313.19 | | EINECS: | | | Product Categories: | | | Mol File: | 2379550-82-8.mol |  |
| | SHS4121705 Chemical Properties |
| Boiling point | 338.3±52.0 °C(Predicted) | | density | 1.81±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | -2.30±0.20(Predicted) |
| | SHS4121705 Usage And Synthesis |
| Biological Activity | SHS4121705 is an orally bioavailable mitochondrial uncoupler.1 It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH). | | References | 1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020) |
| | SHS4121705 Preparation Products And Raw materials |
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